Non-antibiotic alternatives to preventing urinary tract infections

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GAG layer replacement therapy

INTERACTIONS

The potential for drug interactions is likely to be minimal.²¹ No interactions between GAG layer replacement therapy products and other medications are known or have been observed, but there have been no studies undertaken on the use in children, or during pregnancy and lactation.¹⁸

CONTRAINDICATIONS

There are no known contraindications deriving from the use of the device apart from hypersensitivity to any of the components.¹⁸

HANDLING

Products for intravesical instillation of GAG layer replacement therapy are classified as medical devices, with a sterile solution presented in a prefilled syringe or in a vial.¹⁸ The solution is administered via a catheter or special adapter. Standard procedures should be undertaken to reduce the risk of infection and contamination during administration.

SIDE EFFECTS

These products are composed of naturally occurring compounds with very low probability to induce an immune response. Side effects are likely to be minimal,²¹ but treatment should be suspended in the event of the onset of any undesired effect.¹⁸

INTERACTIONS

CONTRAINDICATIONS

There are no known contraindications deriving from the use of the device apart from hypersensitivity to any of the components.¹⁸

HANDLING

SIDE EFFECTS

What is the evidence for GAG layer replacement therapy?

Various studies have investigated the effectiveness of CS and HA combination GAG layer replacement therapy, with a short summary in the table below:

AUTHOR	REDUCING rUTI RATES	IMPROVING URINARY SYMPTOMS	IMPROVING QUALITY OF LIFE	WELL-TOLERATED
Cicione et al¹⁹
Damiano et al²²
De Vita et al²³
De Vita et al²⁴
Goddard et al²⁵

Additional findings include:

GAG layer replacement therapy with CS and HA was found to be more effective than long-term antibiotic prophylaxis for preventing rUTIs.²⁶
The effectiveness of GAG layer replacement therapy was found to improve over time, with an even better expected comparative effectiveness profile in the long run. This is in contrast with the effect of long-term antibiotic prophylaxis, where side effects and the development of resistance are important considerations.²⁷

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INTERACTIONS

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HANDLING

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INTERACTIONS

CONTRAINDICATIONS

HANDLING

SIDE EFFECTS

Non-antibiotic alternatives to preventing urinary tract infections

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GAG layer replacement therapy

INTERACTIONS

CONTRAINDICATIONS

HANDLING

SIDE EFFECTS

INTERACTIONS

CONTRAINDICATIONS

HANDLING

SIDE EFFECTS

What is the evidence for GAG layer replacement therapy?

Non-antibiotic alternatives to preventing urinary tract infections

Continue Module

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