GAG layer replacement
GAG layer replacement therapy
What is the glycosaminoglycan (GAG) layer?
The GAG layer is a natural barrier that protects the bladder lining from urine.18 If this barrier is damaged, irritants and bacteria in urine can come into direct contact with the bladder lining and cause damage to the tissue.18,19 This damage is associated with increased bacterial adherence and development of a UTI.9
The main structural families of GAGs include chondroitin sulphate (CS), dermatin sulphate, heparin sulphate and hyaluronic acid (HA).20
What is GAG layer replacement therapy?
GAG replacement therapy can contain either CS or HA, or both. CS is one of the most abundant GAG molecules located on the bladder wall20,21 and HA is one of the most integral components of the GAG layer. GAG replacement therapy combining these two components20 is designed to facilitate faster and more effective restoration of the bladder epithelium
How does GAG therapy work?
GAG components are administered directly into the bladder where they help repair damage to the GAG layer and restore the bladder’s protective coating, which in turns relieves urinary symptoms.18 The administration procedure is simple to follow and there are options which mean patients can be taught how to do this themselves. Treatment regimens vary depending on the specific choice of treatment.