Additional advice

Haleon Cold and Flu Nurse All in One 500mg/100mg/6.1mg Capsules, hard (paracetamol, guaifenesin, phenylephrine hydrochloride). Indications: Relief of symptoms associated with colds and flu and the pain and congestion of sinusitis, including aches and pains, headache, blocked nose and sore throat, chills, lowering of temperature, and loosening stubborn mucous to relieve chesty coughs. Dosage: Adults, the elderly and children aged 16 years and over: Two capsules every four hours as required. Maximum 8 capsules (4 doses) in any 24 hour period. Do not take continuously for more than 5 days without medical advice. Contraindications: Known hypersensitivity to any of the ingredients. Concomitant use of other sympathomimetic decongestants. Phaeochromocytoma. Closed angle glaucoma. Hepatic or severe renal impairment, hypertension, hyperthyroidism, an enlargement of the prostate gland, diabetes, heart disease or those taking tricyclic antidepressants or beta-blocking drugs and those patients who are taking MAOI or have taken within the last two weeks. Warnings and precautions: Contains paracetamol. Concomitant use of other paracetamol-containing products or use of other cold and cough medicines, including cough suppressants and sympathomimetics (decongestants, appetite suppressants and amphetamine-like psychostimulants), should be avoided. Medical advice should be sought before use in patients with occlusive vascular disease, glutathione depletion due to metabolic deficiencies, chronic cough such as occurs with smoking, asthma, chronic bronchitis or emphysema. Use in caution in patients taking digoxin, cardiac glycosides and vasoconstrictor agents such as ergot alkaloids. Side effects: See SPC for full details. Hypersensitivity reactions including skin rashes, urticaria, allergic dermatitis, angioedema, and anaphylaxis. Bronchospasm, hepatic dysfunction, thrombocytopenia, agranulocytosis and acute pancreatitis. Nervousness, irritability, restlessness, excitability, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, abdominal discomfort, diarrhoea, dysuria and urinary retention. Tachycardia, palpitations, dyspnoea. Legal category: GSL. Product licence number: PL 44673/0019. MAH: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, UK. RRP (excl. VAT): 8’s, £3.18, 16’s, £4.80. Text prepared: August 2023.

Night Nurse / Night Nurse Capsules (paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide). Indications: Night Nurse / Night Nurse Capsules (paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide). Dosage: Adults and children 16 years and over: 20 ml or 2 capsules before bed. Maximum daily dose: Only one dose should be taken per night. Allow at least four hours between taking any paracetamol-containing product and this product. Do not take if you have already taken 4 doses of a paracetamol containing product during the day. Max duration of use is 3 days. Not to be given to children under 16 years except on medical advice. Contraindications: Hypersensitivity to the active ingredients or any of the excipients. Patients with or at risk of developing respiratory failure and patients taking or have taken monoamine oxidase inhibitors (MAOIs) in the last two weeks. Warnings and precautions: Contains paracetamol. Avoid use of other antihistamine-, paracetamol- and decongestant-containing preparations, including topical and cough and cold medicines. Medical advice must be sought for patients with severe hepatic or renal impairment, chronic or persistent cough, cough accompanied by excessive secretions, depleted glutathione levels due to metabolic insufficiencies, narrow angle glaucoma, cardiovascular problems, prostatic hypertrophy, urinary retention, epilepsy. Also seek medical advice for those taking tricyclic antidepressants, selective serotonin reuptake inhibitors, CNS depressants and anticholinergics. Use with caution in elderly. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency (Night Nurse Capsules only) or glucosegalactose malabsorption should not take this medicine. Avoid alcohol. Prolonged use may lead to addiction, even at therapeutic doses. Cases of dextromethorphan abuse and dependence have been reported. Concomitant use with serotonergic agents can result in serotonergic effects, including serotonin syndrome, which should trigger discontinuation of the product. Caution should be exercised in patients who are slow metabolizers of CYP2D6 or use CYP2D6 inhibitors. Medical advice should be sought if symptoms persist, or are accompanied by high fever, skin rash or persistent headache. May cause urine pregnancy tests to produce false results. Liquid only: Contains 18% v/v ethanol per dose - Harmful for those suffering from alcoholism. Contains12.8g glucose and 3mg sodium per dose - Caution must be taken in patients with diabetes mellitus and those who are on a low sodium diet. Side effects: See SPC for full details. Hypersensitivity reactions including anaphylaxis and skin reactions, such as skin rashes, angioedema, SJS, drug dependence and drug withdrawal syndrome, serotonin syndrome, blood dyscrasias, bronchospasm, hepatic dysfunction, gastrointestinal disturbance, nausea, vomiting, abdominal discomfort, drowsiness and dizziness, confusion, paradoxical excitation, psychomotor impairment, disturbance in attention, headache, dry mouth, eye disorders, blurred vision, urinary retention. Legal category: P. Product licence number: PL 44673/0070, 0071 MAH: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, U.K. RRP (excl. VAT): Liquid: £7.49. Capsules: £4.99 Text prepared: April 2023.

Panadol Advance 500 mg Tablets (Paracetamol). Indications: For the treatment of most painful and febrile conditions, including symptomatic relief of pain due to non-serious arthritis. Dosage and administration: Adults and children, 16 years and over: One or Two tablets up to four times daily as required. Max. 8 tablets in 24 hours. Children 10-15 years: One tablet four times daily as required. Max. 4 tablets in 24 hours. Do not use for more than 3 days without doctor’s advice. Doses should not be repeated more frequently than every 4 hours. Children under 10 years: Not recommended. Contraindications: Known hypersensitivity to ingredients. Warnings and Precautions: Do not use with any other paracetamol-containing products. Those with renal or hepatic impairment should seek advice before use. Patients with persistent headaches or those with nonserious arthritis who need to take painkillers every day should consult a doctor. Use with caution in patients with glutathione depletion due to metabolic deficiencies. Side effects: hrombocytopenia, agranulocytosis, anaphylaxis, cutaneous hypersensitivity reactions including skin rash, and angioedema. Bronchospasm and hepatic dysfunction. Legal category: GSL: 16s, P: 30s. Product licence number: GSL: PL 44673/0080. P: PL 44673/0185. Product licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, United Kingdom. RRP (excl. VAT): GSL:16s £1.38, P: 30s £2.48. Text prepared: May 2023.

Anadin Extra (aspirin, paracetamol, caffeine) Indications: For the treatment of mild to moderate pain Dosage: Adults, the elderly and young persons aged 16 and over: 2 tablets every 4 hours. Maximum 8 tablets in 24 hours. Do not give to children aged under 16 years. Contraindications: Hypersensitivity to the active ingredients or any of the other constituents. Current and history of peptic ulceration; haemophilia, concurrent anti-coagulant therapy; children under 16 years and when breast feeding. Warnings and precautions: Caution should be exercised in patients with asthma, allergic disease, impairment of hepatic or renal function (avoid if severe) and dehydration. Do not take if you have a stomach ulcer or with any other paracetamolcontaining medicine. Paracetamol may cause severe skin reactions. In the event of a skin reaction stop use immediately and seek medical advice. Side effects: Refer to the SPC for full details. Gastrointestinal irritation with slight asymptomatic blood loss, increased bleeding time. Aspirin: Bronchospasm, asthma attacks, hypersensitivity reactions, skin reactions including angioedema and face oedema. Gastrointestinal haemorrhage, gout, Reye’s syndrome in children under 16 years. Paracetamol: Skin reactions, blood dyscrasias. Caffeine: Tremor and palpitations Legal category: GSL Product licence number: PL 44673/0199 MAH: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, U.K. RRP (excl VAT): 8s: £1.53 12s: £2.00 16s: £2.53 32s: £3.75 Text prepared: Aug 2023

Robitussin Chesty Cough Medicine. (Guaifenesin 100 mg/5 ml.). Indications: Expectorant for the treatment of coughs. Dosage: Adults, the elderly and children over 12 years: One 10ml measure up to four times daily. Contraindications: Hypersensitivity to any of the ingredients. Use in children under 12 years. Warnings and precautions: Exclude causes of chronic cough if symptoms are persistent. Treat any accompanying symptoms. If the cough lasts more than 7 days, comes back or is accompanied by a fever, rash or persistent headache, stop use and speak to a healthcare professional. Contains sorbitol and maltitol, those with rare hereditary problems of fructose intolerance should not take this product. This medicine contains 242 mg ethanol in each 10ml dose (2.3% w/v), take into account in pregnant or breast-feeding women and high-risk groups. Contains 12 mg sodium benzoate, 15.2 mg propylene glycol and 23.9 mg sodium per 10ml dose. Contains 2675 mg sorbitol per dose which may cause gastrointestinal discomfort or a mild laxative effect. Side effects: Nausea, vomiting, hypersensitivity reactions. Legal category: GSL. Product licence number: PL 44673/0206 MAH: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, U.K. RRP (excl. VAT): 100ml £4.58. 250ml £7.50. Text prepared: November 2023

Robitussin Dry Cough Medicine. (Dextromethorphan hydrobromide 7.5 mg/5 ml). Indications: For the relief of persistent dry irritant coughs. Dosage: Adults, the elderly and children over 12 years: One 10 ml measure up to four times daily. Contraindications: Hypersensitivity to any of the ingredients. Use of a monoamine oxidase inhibitor (MAOI), a selective serotonin reuptake inhibitor (SSRI), or other medication for Parkinson’s disease, depression, psychiatric, or emotional conditions, or for 14 days after stopping the medication. Use in children under 12 years. Warnings and precautions: Patients suffering from chronic cough as occurs with smoking, asthma or patients suffering from an acute asthma attack, or where cough is accompanied by excessive secretion should be advised to consult a Healthcare Professional before use. Exclude causes of chronic cough if symptoms are persistent. Investigate/treat any accompanying symptoms appropriately. Stop use and seek medical advice if the cough lasts more than 7 days, comes back or is accompanied by a fever, rash or persistent headache. Cases of dextromethorphan abuse and dependence have been reported. Caution is particularly recommended for adolescents and young adults as well as in patients with a history of drug abuse or psychoactive substances. Caution in patients who are slow metabolizers of CYP2D6 or use CYP2D6 inhibitors as they may experience exaggerated and/or prolonged effects. Contains sorbitol and maltitol: Patients with rare hereditary problems of fructose intolerance should not take this medicine. Contains 23mg sodium and 12mg sodium benzoate per 10 ml dose. Contains amaranth (E123), which may cause allergic reactions. Contains 219.3mg ethanol per 10 ml dose, which should be taken into account in pregnant or breast-feeding women or in high-risk groups. Contains 2094mg sorbitol per 10 ml dose, which may cause gastrointestinal discomfort and mild laxative effect. Serotonergic effects have been reported following concomitant administration of SSRIs, MAOIs and CYP2D6 inhibitors, and if suspected, treatment should be discontinued. Side effects: Hypersensitivity. Rare: Gastrointestinal upset, dizziness, drowsiness, mental confusion. Frequency Unknown: Drug dependence or drug withdrawal syndrome. Legal category: P. Product licence number: PL 44673/0207. MAH: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, U.K. RRP (excl. VAT): 100ml £4.58. 250 ml £7.50 Text prepared: November 2023

Otrivine Extra Dual Relief 0.5 mg/ml + 0.6 mg/ml nasal spray, solution. (0.5 mg/ml xylometazoline hydrochloride and 0.6 mg/ml ipratropium bromide). Indications: Symptomatic treatment of nasal congestion and rhinorrhea in connection with common colds. Dosage: Adults: 1 puff in each nostril, up to 3 times daily, with at least 6 hours between doses. Maximum 3 applications daily into each nostril. Do not exceed the stated dose. Do not use for longer than 7 days. Geriatrics: Limited experience of use in patients above 70 years of age. Contraindications: Children and adolescents under 18 years. Known hypersensitivity to xylometazoline hydrochloride, ipratropium bromide, any of the excipients, atropine or atropine-like substances. Patients with glaucoma, rhinitis sicca, atrophic rhinitis or following trans-sphenoidal hypophysectomy or surgery exposing the dura mater. Warnings and precautions: Use with caution in people with: hypertension, cardiovascular disease, long QT syndrome, hyperthyroidism, diabetes mellitus, prostatic hypertrophy, bladder stenosis, pheochromocytoma, on monoamine oxidase inhibitors treatment or tri/tetra cyclic antidepressants (or have been on either within the last two weeks), on beta 2-agonist treatment, cystic fibrosis. Use with caution in patients predisposed to angle closure glaucoma, epistaxis or paralytic ileus. Immediate hypersensitivity including urticaria, angioedema and rash may occur. Caution in people sensitive to adrenergic substances. Avoid contact with eyes. Side effects: See SPC for full details. Very common: epistaxis. Common: dysgeusia, rhinalgia, nasal congestion, headache, nasal dryness, nasal discomfort, nausea, application site burn, dizziness, throat irritation, dry throat, dry mouth. Uncommon: insomnia, parosmia, tremor, eye irritation, dry eye, palpitations, tachycardia, nasal ulcer, sneezing, dyspepsia, fatigue, corneal oedema, cough. Price: £6.66 (ex. VAT) Legal Status: P. Licence Number: PL 15545/0002. Licence Holder: GlaxoSmithKline Dungarvan Limited, Knockbrack, Dungarvan, County Waterford, Ireland. Date of revision: October 2023